What Is Bladder Cancer: Overview

To understand the benefits of UroVysion, you need to understand bladder cancer. 

Bladder cancer is the fifth most common cancer in the United States, with over 50,000 newly diagnosed cases and over 12,000 deaths annually2. Bladder cancer is three times more likely to occur in men than in women. The median age at diagnosis is 65 years; bladder cancer is rare in individuals under 402.

The recurrence rate for bladder cancer is 70 percent; of the approximately 600,000 Americans living with bladder cancer, it is estimated that nearly 400,000 are at risk for recurrence1.

In men, bladder cancer is the fifth most common malignant tumour in Europe and the fourth most common in the USA. In American women it is the 8th most common cancer.

  TotalMale Female 
Bladder Cancer449,635330,868118,767
Lung Cancer326,895170,608156,287
Prevalence of bladder cancer in the U.S., Source NCI 2002 Fact Sheet    
Bladder cancer prevalence is steadily increasing. The projected rise is 28% by 2010 for both men and women. In a 2002 factsheet for the public from the NCI, it was reported that the prevalence of bladder cancer in the U.S. surpassed that of lung cancer:

Bladder Cancer Risk Factors
Smoking is the greatest risk factor for bladder cancer, with smokers experiencing twice the risk of nonsmokers for developing the disease. Individuals living in urban areas - especially the American northeast - and those working in the dye, rubber, or leather industries are also at higher risk.

Bladder Cancer Symptoms
The chief initial symptom of bladder cancer is hematuria, or blood in the urine.

Over 90% of bladder cancers in western, industrialized countries are Transitional Cell Carcinomas, so called because these cells have the capability to undergo changes in size from cubical (when the bladder is empty) to flat (when the bladder is full).  With such a high rate of recurrence (>70%), it's important to regularly monitor for transitional cell carcinoma recurrence so that it is more likely to be caught early.  UroVysion can benefit the physician who is monitoring for recurrence of bladder cancer.

References

1.Ta, T1 Bladder Cancer: What Can We Learn From EORTC Trials? APM van der Meijden Department of Urology, Bosch Medicentrym, Den Bosch, The Netherlands

2. Memorial Sloan Kettering website; http://www.mskcc.org/

The UroVysion Bladder Cancer Kit (UroVysion Kit) is designed to detect aneuploidy for chromosomes 3, 7, 17, and loss of the 9p21 locus via fluorescence in situ hybridization (FISH) in urine specimens from persons with hematuria suspected of having bladder cancer. Results from the UroVysion Kit are intended for use, in conjunction with and not in lieu of current standard diagnostic procedures, as an aid for initial diagnosis of bladder carcinoma in patients with hematuria and subsequent monitoring for tumor recurrence in patients previously diagnosed with bladder cancer.